When Boston College travels down Commonwealth Avenue to take on UConn at Fenway Park on Saturday night, Darius Wade will be at the helm of the Eagles’ offense for the first time in more than two years.

Last Saturday, with 13:08 remaining in the second quarter of the BC’s 17-14 loss to North Carolina State, starting quarterback Anthony Brown scrambled out of the pocket trying to make something out of nothing, but when the redshirt freshman planted to make a cut, his right knee buckled inward. He lay on the turf until help came, and then was assisted off the field.

He did not return, and on Monday BC coach Steve Addazio confirmed that Brown’s season is over. He will undergo surgery, and is expected to be ready for next year.

Wade, who was BC’s starting quarterback at the beginning of the 2015 season before suffering a season-ending broken ankle in the third game of the season, battled for the starting job each of the last two seasons but was beaten out by graduate transfer Patrick Towles last year and then Brown this year. Now, the redshirt junior the Eagles’ starter once again.

BC stands at 5-5 overall and 3-4 in the ACC with two games remaining. If they Eagles are to reach a bowl game for the fourth time in five years Wade will be the one to lead them.

“We've lost Anthony Brown for the season,” Addazio said on Monday afternoon at the start of his weekly press conference. “Anthony has a lower leg injury that will require surgery. So we'll be moving forward. Obviously, our heart goes out to Anthony. He's a big part of the future of our program, and he's a great competitor. He'll be back ready to roll next year, and we'll have had a great year behind his belt to prepare for another great year from now.

“But as we've had to do all year long, we've got to pick it up and keep going.”

With Brown at quarterback, after some struggles early in the season, the BC offense was soaring.

Prior to Saturday’s loss, the Eagles had scored 121 points in their previous three games — all wins over ACC opponents — and hadn’t scored fewer than 35. And prior to Brown’s injury on Saturday, though BC hadn’t scored, it had driven into the red zone on two of its three possessions and into N.C. State territory on the other.

Once Wade entered, however, the Eagles weren’t able to sustain drives, scoring only on a 66-yard run by freshman A.J. Dillon and after N.C. State turned the ball over deep in its own territory.

Wade was repeatedly sacked at key moments, once setting the Wolfpack up for easy points when he fumbled after getting hit from behind by Bradley Chubb, and otherwise destroying potential drives. On the opening possession of the third quarter, for example, BC advanced from its 17-yard line to the N.C. State 36, but then Chubb sacked Wade for a 7-yard loss, and after Wade completed a pass for a 4-yard loss he was sacked for a 5-yard loss.

Wade has his strengths, but one of Brown’s is the ability to get rid of the ball quickly, which is something Wade does not do.

“We run a quick game,” said Addazio. “Ball's got to be out. … We call that ball security. Everybody's responsible. There's a lot of ways to account for ball security — running backs got to carry it high and tight, line’s got to do a great job protecting, quarterback’s got to get the ball out, receiver’s got to run precise routes and get open. Those all go into ball security. And there's a lot of factors that go in here.

“I think our emphasis will be on making sure that we have great timing this week and the ball's out in rhythm on time.”

With Brown out for the season and Wade now the starter, true freshman E.J. Perry becomes the backup. If he plays, it will burn his redshirt. In addition, junior quarterback-turned-receiver Jeff Smith will return to his roots and take some snaps in practice.

“E.J. Perry is completely on board and ready to play,” said Addazio. “So that's already been discussed early with he and his family, and he has a tremendous, competitive mindset. As he said, ‘I came here to be part of this team. I came here because it's a privilege, not a right. I'm going to do everything I can to help this football team win, whether you need me for one snap or 50.’ You've got to appreciate that kind of mindset from a competitor. He's ready to roll. Darius is ready to roll.

“We'll get Jeff Smith some snaps because John Fadule is out for the year as well.”

BC’s season has been marked by devastating injuries, starting the second week of the season when starting center Jon Baker suffered a torn ACL while his backup was also hurt, forcing true freshman Ben Petrula into duty. The Eagles, however, had been able to overcome the losses of Baker, Connor Strachan, Max Richardson, Charlie Callinan, and others.

Now they must try to overcome the loss of Brown, and Wade’s play will be the determining factor.

Eric Avidon can be reached at 508-626-3809 or eavidon@wickedlocal.com. Follow him on Twitter @ericavidon.